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Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over
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| Published in: | Scientific reports 7(2017) Artikel-Nummer 11683, 10 Seiten; extent:10; volume:7; year:2017 |
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| Authors and Corporations: | , , , , , , , |
| Other Authors: | Benck, Urs Tobias 1966- [Author] • Breedijk, Annette 1960- [Author] • Leikeim, Lisa 1993- [Author] • Porubský, Štefan 1977- [Author] • Krämer, Bernhard 1957- [Author] • Yard, Benito A. 1961- [Author] • Kälsch, Anna-Isabelle [Author] |
| Type of Resource: | E-Book Component Part |
| Language: | English |
| published: |
15 September 2017
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| Series: |
Scientific reports, 7(2017) Artikel-Nummer 11683, 10 Seiten
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| Source: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| ISSN: | 2045-2322 |
| Summary: | Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV) patients, an impaired expression of these molecules on T-cells of AAV patients was hypothesized in the present study. While in AAV patients (n = 29) CD26 was increased on CD4+ lymphocytes, CD39 and CD73 were generally reduced on patients’ T-cells. In CD4+ cells significant differences in CD73 expression were confined to memory CD45RA- cells, while in CD4- lymphocytes differences were significant in both naïve CD45RA+ and memory CD45RA- cells. The percentage of CD4-CD73+ cells correlated with micro-RNA (miR)−31 expression, a putative regulator of factor inhibiting hypoxia-inducible factor 1 alpha (FIH-1), inversely with serum C-reactive protein (CRP) and positively with estimated glomerular filtration rate (eGFR). No correlation with disease activity, duration, and ANCA profile was found. It remains to be assessed if a decreased CD73 and CD39 expression underlies functional impairment of lymphocytes in AAV patients. Likewise, the relations between frequencies of CD4-CD73+ cells and serum CRP or eGFR require further functional elucidation. |
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| Item Description: | Gesehen am 13.08.2018 |
| Physical Description: | 10 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-12011-4 |