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3-T T2 mapping magnetic resonance imaging for biochemical assessment of normal and damaged glenoid cartilage: a prospective arthroscopy-controlled study

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Published in: Scientific reports 10(2020) Artikel-Nummer 14396, 11 Seiten
Authors and Corporations: Wünnemann, Felix (Author), Kintzelé, Laurent (Author), Braun, Alexander (Author), Zeifang, Felix (Author), Maier, Michael Wolfgang (Author), Burkholder, Iris (Author), Weber, Marc-André (Author), Kauczor, Hans-Ulrich (Author), Rehnitz, Christoph (Author)
Other Authors: Kintzelé, Laurent 1990- [Author] • Braun, Alexander 1985- [Author] • Zeifang, Felix 1967- [Author] • Maier, Michael Wolfgang 1979- [Author] • Burkholder, Iris [Author] • Weber, Marc-André 1973- [Author] • Kauczor, Hans-Ulrich 1962- [Author] • Rehnitz, Christoph 1976- [Author]
Type of Resource: E-Book Component Part
Language: English
01 September 2020
Series: Scientific reports, 10(2020) Artikel-Nummer 14396, 11 Seiten
Source: Verbunddaten SWB
Lizenzfreie Online-Ressourcen
ISSN: 2045-2322
Summary: This study evaluated the ability of T2 mapping to assess the glenoid cartilage using arthroscopy as the gold standard. Eighteen consecutive patients (mean age: 52.4 ± 14.72 years, including 12 men) with shoulder pain underwent T2 mapping at 3-T with subsequent shoulder arthroscopy. With correlation to cartilage-sensitive morphologic sequences regions-of-interest were placed in the corresponding T2 maps both in normal-appearing cartilage and focal cartilage lesions using a quadrant-wise approach. Inter-reader and intra-reader correlation coefficients (ICCs) between two independent radiologists as well as cut-off values with their sensitivities/specificities for the detection of cartilage damage were calculated. The mean T2 value for healthy cartilage was 23.0 ± 3 ms with significantly higher values in the superior quadrants compared to the inferior quadrants (p < 0.0001). In 5 patients with focal cartilage damage significantly higher T2 values of 44.7 ± 3.7 ms (P < 0.01) were observed. The maximum T2 value in normal cartilage (27.3 ms) was lower than the minimum value in damaged cartilage (40.8 ms) resulting in perfect sensitivities/specificities of 100% (95% confidence-interval 47.8-100.0) for all cut-off values between 27.3-40.8 ms. ICCs ranged between 0.63 and 0.99. In conclusion, T2 mapping can evaluate biochemical cartilage integrity and discriminates arthroscopy-proven healthy and damaged glenoid cartilage with high diagnostic performance.
Item Description: Gesehen am 15.10.2020
Physical Description: 11
ISSN: 2045-2322
DOI: 10.1038/s41598-020-71311-4